|State Championships||2015 MSHSAA Class 4|
|National Appearances||2010 HSNCT|
Clayton High School is a public high school in Clayton, Missouri. Once a dominant factor in Missouri Quizbowl, the team experienced a resurgence in 2015. Led by Omkar Venkatesh, the school went undefeated in the 2015 MSHSAA Class 4 State Championship to win the school's first state title.
Under the leadership of Ikshu Neithalath, Clayton was widely considered to be the second-best team in the state in 2011, behind Ladue . Excluding WUHSAC XIII, the team placed fourth or better in every in-state tournament it attended, either winning or placing behind Ladue at all in-state tournaments Ikshu attended. Clayton was the only Missouri team to place ahead of Ladue at any tournament (2011 Mort Walker Invitational) that season. Despite the team's strength in the 2011 season, due to MSHSAA districts being based on geographic proximity, Clayton was not even able to advance to sectionals in the 2011 MSHSAA State Championship series because it was in the same district as Ladue (which is only four miles away) . They finished 32nd at the 2011 NSC.
From 2012-2014, Clayton experienced several coaching changes and declining appearance at area tournaments. However, the slump ended in 2015 with the team winning its first MSHSAA Championship, led by Omkar Venkatesh and coached by Daniel Glossenger.